Background analysis:

Magnetic imaging technology based on micro-magnetic sensor array has been widely used in the field of biomedicine. The multi-channel cardiomagnetic system is adopted to extract the array cardiomagnetism, brain magnetism, and fetal cardiomagnetic signals. Analysis needs to be conducted by magnetic imaging to realize the visualization analysis and index extraction of the cardiomagnetism, brain magnetism signals, and fetal cardiomagnetic medical information for doctors to interpretate. The cyclical beating of the human heart generates a biological current, which can then generate a weak 100pT magnetic field signal in the chest, and the brain and fetal heart magnetic activity can generate weak signal of 100fT. The magnetocardiogram (MCG) is a non-invasive technique that records changes in the electromagnetic field generated during cardiac activity. It mainly records the MCG signals generated at the tangential direction. Therefore, it can detect both AC and DC magnetic field signals simultaneously, and more actually reflect the electrophysiological condition of human heart. Magnetoencephalography (MEG) is an image technique that studies brain functions by non-invasively detecting weak MEG signals. Generally, it uses the superconducting quantum interference device (SQUID) to collect such weak MCG and MEG signals, processes the signals by professional software and algorithms, and draws the MCG and MEG to detect the patients' heart and brain conditions. Although the SQUID has high precision and sensitivity, it needs to function properly under ultra-low temperature and superconductivity. It is expensive and complicated, and not suitable for wide adoption and replication. Guochuang Micro-magnetic Basic Sensor has the advantages of small volume, low power consumption, high precision, high sensitivity, high cost performance, high reliability and convenient operation, etc. It is widely used in MCG and MEG detections.

 Functions:

Compared with the electrocardiogram (ECG), the magnetic signal of the human body is weaker than the electrical signal, but it is more stable. Because the human tissue is composed of non-magnetic substances and will not be interfered by media such as chest wall and ribs, the result is more reliable. The theoretical sensitivity of the micro-magnetic basic sensor with GMI effect can reach 10fT (1×10^-14T), so it can measure cardiomagnetism, brain magnetism and fetal cardiomagnetism, and it has the potential advantage of replacing SQUID, which will further reduce medical costs, and make contributions to the promotion of the application of MCG, MEG and fetal MCG.

 

 Principle:

The redox reaction in the human body causes electron transfer or ion movement, generating bioelectric current. As the moving charge generates a magnetic field, the part that produces a bioelectrical signal generates a biomagnetic signal. The MCG signal is mainly derived from the current generated by the flow of charged ions between the cell membranes of the heart tissue, which is triggered by the electrical activity of the heart. The main source of the magnetic field measured by MEG is the postsynaptic potential generated by the dendrites of the cone cells of the cerebral cortex. The fetal MEG is weaker than the adult MEG. Guochuang Micro-magnetic Basic Sensor utilizes the GMI effect, that is, the principle that the impedance of the sensitive material changes greatly due to the variation of the magnetic field. It can detect weak biomagnetic signals.

 Technical solution:

Guochuang Micro-magnetic Basic Sensor is adopted as a multi-channel MCG, MEG or fetal MCG detection probe, and the collected multi-channel MCG and ME signals, and fetal MCG cardio-magnetic signal are entered into special software for filtering, calculation and display. The MCG, MEG and fetal will be drawn, which can be used for pathological detection and analysis of heart, brain and fetal heart.

 

 

 The main components of the system:

1. Guochuang Magnetic Imaging Medical Device is composed of micro-magnetic basic sensor array, communication module, digital signal unit, etc.;

2. The micro-magnetic basic sensor array produces a gradient magnetic sensor according to multiple channels to ensure the collection and monitoring of the weak magnetic information of heart and brain;

3. Related algorithms include: micro-magnetic basic sensor array calibration, environmental noise suppression, processing of magnetic anomaly targets small signal, etc.;

4. Data center: collection of data and information such as micro-magnetic basic sensor array data and magnetic anomaly imaging signals;

5. Terminal console: display the working status and magnetogram information of Guochuang Magnetic Imaging System.